Artificial sweeteners commonly used in foods and drinks have a toxic effect on digestive gut microbes.
According to a study published in the journal Molecules, researchers found that six 
common artificial sweeteners approved by the Food and Drug Administration and 10 sport supplements that contained them were found to be toxic to the digestive gut microbes of mice.
This article comes from US News and World, published Oct. 1, 2018. HERE is a link to the full article.
More information:
The Environmental Working Group previously published their article called “Low-calorie sweeteners: Are they better or worse for you than sugar?”
Organic Products are Healthier 